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Changes in the uterine and umbilical circulations after intra-aortic injection of prostaglandin E2 (PGE2) or prostaglandin F2α (PGF2α) to either the fetus or the mother have been examined in 13 ewes at late gestation. PGF2α given to either the fetus or the mother is vasoconstrictive in both uterine and umbilical circulations. PGE2 given to the fetus results in a dissociated response with vasodilation of the uterine circulation and vasoconstriction of the umbillcal circulation. PGE2 given to the mother causes a uterine contraction that precludes specific hemodynamic analysis. Therefore, exposure of either maternal or fetal ovine circulation to exogenous prostaglandins is associated with acute changes in both placental circulations. Similar responses to pertubations in endogenous prostaglandin levels may exist in pregnant sheep.
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☆Presented at the Twenty-fourth Annual Meeting of the Society for Gynecologic Investigation, Tucson, Arizona, March 23–25, 1977.